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柱芳烃特有的柱状结构和富电子空腔，使其具有独特的主客体络合能力，结构易于修饰的特性也使其在很多方面得到了广泛应用。为了提高肿瘤的治疗效果，主动靶向药物递送体系变得尤为重要。得益于柱芳烃优异的结构可变性，肿瘤靶向基团可以很容易地被引入到基于柱芳烃的药物递送体系中，以实现肿瘤部位的精准药物递送。文章总结了现阶段基于柱芳烃的主动靶向药物递送体系的设计策略：第一种策略是通过主客体络合引入靶向基团，将靶向基团通过非共价键的方式引入到药物递送体系，避免了复杂的有机合成；另一种更加直接的方法就是设计合成靶向基团修饰的柱芳烃，基于靶向基团修饰的柱芳烃的靶向药物递送体系靶向能力稳定性强，重现性大，但是这一方法往往需要成本较大的有机合成。
Abstract：Pillararenes feature columnar structures with electron-rich cavities, enabling distinctive host-guest comple-xation properties, while their structural adaptability supports diverse applications. In the context of improving cancer treatment outcomes, active targeted drug delivery systems(DDSs) are recognized as vital. The inherent structural flexibility and host-guest interactions of pillararenes facilitate the integration of tumor-targeting groups into pillararene-based DDSs, allowing precise drug delivery to tumor sites. This review delineates two design strategies for such systems. One approach employs host-guest complexation to incorporate targeting groups through noncovalent bonds,avoiding the need for intricate organic synthesis. Alternatively, pillararenes modified with targeting groups are synthesized directly, yielding DDSs with stable targeting capabilities and consistent reproducibility, albeit at the expense of increased time and cost due to complex organic synthesis processes.
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基本信息:
DOI：10.12194/j.ntu.20231113001
中图分类号:TQ460.1
引用信息:
[1]全慧,卢冰.基于柱芳烃的主动靶向药物递送体系的设计策略[J].南通大学学报(自然科学版),2025,24(01):85-94.DOI:10.12194/j.ntu.20231113001.
基金信息:
国家自然科学基金青年科学基金项目（32301184）
2024-02-02
2024-02-02
2024-02-02